‘Roadmap’ tracks trajectories of embryo development

BBI scientists and others have mapped out the key molecular changes that orchestrate how embryonic mouse cells differentiate into the diverse cell types that will ultimately form all the different tissues and organs of the adult animal.

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Image of Mouse Embryo Image of mouse embryo -- Ian Welsh and Stephen Murray | Jackson Laboratory

BBI scientists and others have mapped out the key molecular changes that orchestrate how embryonic mouse cells differentiate into the diverse cell types that will ultimately form all the different tissues and organs of the adult animal.

This “roadmap” of mouse embryogenesis will help researchers understand the molecular programs that control how different specialized cell types emerge from less differentiated cells as an embryo grows and develops not only for mice, but also for humans, said Jay Shendure, professor of genome sciences at the University of Washington School of Medicine, scientific director of the Brotman Baty Institute for Precision Medicine and a Howard Hughes Medical Institute Investigator.

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