Our Research Defines Us

The goal of BBI’s tools and platforms is to enable our members to explore new opportunities at the interface of basic science and precision medicine.

Below are some recent examples of our work.

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Sea Hub

SeaBridge

Lead Researchers

Jay Shendure

Marion Pepper

Cole Trapnell

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Sea Hub

The Brotman Baty Institute & The Seattle Hub for Synthetic Biology

Lead Researchers

Jay Shendure, Cole Trapnell, Marion Pepper, Sud Pinglay, Nobuhiko (Nobu) Hamazaki

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Mutational Scanning

Variant Effects Program

Lead Researchers

Lea Starita, Doug Fowler, Jay Shendure, Andrew Stergachis

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Genomics

BBI Advanced Technology Lab

Lead Researchers

Lea Starita

Jay Shendure

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Welcome to The Brotman Baty Institute

Welcome to The Brotman Baty Institute, an innovation hub for genomic research and precision medicine.

The BBI is a collaboration among Seattle’s three top research institutions—The University of Washington, Seattle Children’s Hospital, and Fred Hutchinson Cancer Research Center.

The offices of the Brotman Baty Institute and the UW Campus overlook Seattle’s Montlake Cut, Lake Union, and the city skyline. Photo courtesy of University of Washington Communications.

Our Resources

Investigators based at partner institutions have equal access to our platforms at identical costs.

Tools & Data

BBI tools and data support BBI members and researchers worldwide.

BBI provides data and a repository for our datasets, analysis code, and protocols. We also provide tutorials to assist you in downloading, analyzing, and exploring these datasets.

See Tools

Platforms

BBI Platforms support our research.

Our goal is to support the work of our faculty, researchers, and investigators by fostering collaboration and innovation.

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BBI Grant Program

The BBI invests in promising pilot research.

The Brotman Baty Institute (BBI) aims to create a community of investigators across the three founding institutions (UW, Fred Hutch, Seattle Children’s) to advance basic science and translational research with clear relevance to precision medicine. The BBI invests in innovative, collaborative projects that address basic science or translational research questions related to precision medicine. To learn more about the grants offered by BBI and to apply, contact info@brotmanbaty.org.

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Collaborators

BBI members include more than 300 faculty at The University of Washington, Seattle Children’s Hospital, and Fred Hutchinson Cancer Research Center.

"We are better at reading DNA than understanding what we find. Our work at the BBI Advanced Technology lab aims to make 'variants of uncertain significance' a thing of the past."

Lea Starita

University of Washington

“Innovation and inspiration are key elements of BBI’s success.”

Sanjay Srivatsan

Fred Hutch

"BBI places a high value on collaboration and building a sense of 'community' with other researchers to move research forward."

Mary O'Neill

University of Washington

"BBI’s unwavering support for the international Atlas of Variant Effects Alliance has been invaluable in developing, disseminating, and democratizing technologies for mapping genetic variant effects. We feel that we are at a moment where we can actually solve this problem"

Doug Fowler

University of Washington

"BBI brings together faculty from three campuses in a collaborative environment to generate new tools and ideas for the implementation of precision medicine."

Fuki Hisama

University of Washington

Learn about membership at BBI

Our Commitment to Diversity, Equity, and Inclusion

BBI embraces diversity and inclusion in all its work and, like the University of Washington, believes diversity is integral to excellence.

We value and honor diverse experiences and perspectives, strive to create welcoming and respectful learning environments, and promote access, opportunity, and justice for all.

News

Q &A with Ivan Woo on Paper, “Saturation genome editing of BARD1 resolves VUS and provides insight into BRCA1-BARD1 tumor suppression”

December 16, 2025 | by BBI Communications

BBI’s Ivan Woo, a member of the Starita Lab, is the first author on a new preprint paper contributing to the understanding of how changes in the BARD1 gene affect cancer risk

Promising Young Scientist: Elliott Swanson Charts a Cell’s Complete Epigenome

December 03, 2025 | by BBI Communications

‘He’s not only delivered technically, but he’s also translated those advances to illuminate the genetic basis of rare disease’

Seattle Hub’s ‘Sense Team’ Plays Pivotal Role Building Technologies to Record Live Data from Cells

November 24, 2025 | by BBI Communications

‘Building cellular technologies to record and capture live data from millions of cells as those cells change and respond to their environments’

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